A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/18 (2006.01) A61K 31/485 (2006.01) A61K 47/02 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01)
Patent
CA 2690824
The present application relates to formulations having a decreased abuse potential. In a representative embodiment, the formulation comprises methadone hydrochloride (6-(Dimethylamino)-4,4-diphenylheptan-3-one, a synthetic opioid), meglumine, cellulose, lactose and magnesium stearate. The application further illustrates methods for making the formulations. The use of formulations comprising a pharmaceutically acceptable salt of a narcotic drug having one positively charged protonated amine together with an alkalizing agent, for reducing potential for narcotic abuse is described.
La présente invention concerne de nouvelles préparations narcotiques présentant un potentiel réduit d'abus par injection. Dans un mode de réalisation représentatif, la formulation comprend du chlorhydrate de méthadone (6-diméthylamino-4,4-diphénylheptan-3-one, un opioïde synthétique), de la méglumine, de la cellulose, du lactose et du stéarate de magnésium. L'invention porte aussi sur des procédés de fabrication des préparations susmentionnées.
Betancourt Aimesther Ojito
Gosselin Patrick
Vinson Robert
Borden Ladner Gervais Llp
Paladin Labs Inc.
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