Methanediphosphonic acid formulations with ion exchangers

Details Methanediphosphonic acid formulations with ion exchangers Methanediphosphonic acid formulations with ion exchangers

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 31/675 (2006.01) A61K 47/32 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2093946

The invention relates to a novel advantageous oral dosage form for methanediphosphonates, especially the active ingredient disodium pamidronate. A preferred dosage form comprises: a) disodium-3-amino-1-hydroxypropane-1,1-diphosphonate (disodium pamidronate), b) a cationic macroporous ion exchange resin based on a styrene/divinylbenzene copolymer having an exchangeable aminophosphonate group and, where appropriate, c) further pharmaceutically acceptable excipients. The ingredients can be processed to form tablets, dragées, capsules etc..

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