C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 31/336 (2006.01) A61K 31/395 (2006.01) A61K 38/04 (2006.01) A61K 38/08 (2006.01) A61K 38/48 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07D 303/02 (2006.01) C07D 303/16 (2006.01) C07D 303/36 (2006.01) C07D 405/14 (2006.01) C07D 407/00 (2006.01) C07K 5/02 (2006.01) C07K 5/04 (2006.01) C07K 5/06 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01)
Patent
CA 2484189
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.
L'invention concerne des composés inhibant l'angiogenèse qui comprennent un noyau inhibiteur de MetAP-2 couplé à un peptide, et des compositions pharmaceutiques renfermant lesdits composés et un excipient pharmaceutiquement acceptable. L'invention concerne aussi des méthodes permettant de traiter une maladie angiogénique, p. ex. un cancer, chez un sujet, par l'administration à ce sujet d'une quantité thérapeutiquement efficace d'un ou de plusieurs de ces composés inhibant l'angiogenèse.
Arico-Muendel Christopher C.
Birktoft Jens
Cook Charles Michael
Lee Lily
Morgan Barry
Borden Ladner Gervais Llp
Praecis Pharmaceuticals Inc.
LandOfFree
Methionine aminopeptidase-2 inhibitors and methods of use... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methionine aminopeptidase-2 inhibitors and methods of use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methionine aminopeptidase-2 inhibitors and methods of use... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1467891