Methionine sulfone and s-substituted cysteine sulfone...

Details Methionine sulfone and s-substituted cysteine sulfone... Methionine sulfone and s-substituted cysteine sulfone...

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) A61K 38/06 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2188162

This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.

L'invention concerne des composés qui inhibent la thrombine ou le facteur Xa. Lesdits composés contiennent une fonctionnalité aldéhyde et un résidu de méthionine-sulfone ou de cystéine-sulfone substituée en S. Ces composés et les compositions pharmaceutiques qui les contiennent peuvent être utilisés pour prévenir la thrombose chez les mammifères dont on pense qu'ils présentent un état pathologique caractérisé par l'apparition d'une thrombose anormale.

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