Methionine sulfoxide peptide, compositions and methods of use

Details Methionine sulfoxide peptide, compositions and methods of use Methionine sulfoxide peptide, compositions and methods of use

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 8/64 (2006.01) A61P 17/18 (2006.01) A61Q 19/08 (2006.01)

Patent

CA 2757036

Use of a peptide containing an oxidized methionine residue to ameliorate the effects of oxidative stress in human skin. A short polypeptide containing an oxidized methionine at its C-terminus is shown to inhibit the production of Sunburn Cells in living skin models and to upregulate methionine sulfoxide reductase. Cosmetically acceptable compositions and methods of using the polypeptide are disclosed. The oxidized peptide may repair oxidized alpha 1-antitrypsin, which, in turn, inhibits breakdown of connective tissue by elastase. This effect may have wide ranging ramifications, including, for example, repair of sun damaged skin and treatment of emphysema.

La présente invention concerne l'utilisation d'un peptide contenant un résidu de méthionine oxydée pour améliorer les effets du stress oxydatif sur la peau humaine. Il a été montré qu'un polypeptide court contenant une méthionine oxydée à son extrémité C-terminale inhibe la production de cellules « coup de soleil » dans des modèles de peau vivante et sur-régule la méthionine sulfoxyde réductase. L'invention concerne des compositions acceptables sur le plan cosmétique et des procédés d'utilisation des polypeptides. Le peptide oxydé peut réparer l'alpha 1-antitrypsine oxydée, qui, à son tour, inhibe la décomposition du tissu conjonctif par l'élastase. Cet effet peut avoir des ramifications étendues, comprenant par exemple, la réparation de peau endommagée par le soleil et le traitement de l'emphysème.

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