Method

Details Method Method

A - Human Necessities

61

K

A61K 41/00 (2006.01) A61K 31/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2729369

The present invention relates to a method for enhancing the activity of kinase inhibitors in target cells, and more specifically for enhancing the activity of tyrosine kinase inhibitors (TKIs), said method comprising contacting a cell with a kinase inhibitor and a photo sensitizing agent and irradiating said cell with light of a wavelength effective to activate the photosensitizing agent, and to the use of this method for enhancing the effects of kinase inhibitors or kinase inhibitor-based drugs in particular to achieve cell death, for example, in cancer treatment and other diseases or conditions in which kinase inhibitors, such as TKIs, have a beneficial effect.

La présente invention concerne un procédé pour augmenter lactivité dinhibiteurs de kinase dans des cellules cibles et plus spécifiquement pour augmenter lactivité dinhibiteurs de tyrosine kinase (TKI), ledit procédé comprenant la mise en contact dune cellule avec un inhibiteur de kinase et un agent photosensibilisant et lirradiation de ladite cellule avec une lumière dune longueur donde efficace pour activer lagent photosensibilisant, et lutilisation de ce procédé pour augmenter les effets dinhibiteurs de kinase ou de médicaments à base dinhibiteur de kinase en particulier pour obtenir la mort cellulaire, par exemple, dans le traitement du cancer et dautres maladies ou pathologies pour lesquelles des inhibiteurs de kinase, tels que des TKI, ont un effet bénéfique.

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