Method

Details Method Method

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/43 (2006.01) A61K 48/00 (2006.01) A61P 37/04 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 19/18 (2006.01)

Patent

CA 2333159

The invention relates to methods of altering the activity of the PKA signaling pathway by altering, preferably inhibiting, the extent of phosphorylation of PKA substrates or downstream kinase substrates, particularly by the use of modified substrates, gene sequences encoding such modified substrates, vectors and host cells containing the gene sequence, inhibitors of substrate phosphorylation and use of the gene sequence, protein or inhibitors to alter the PKA signaling pathway, for example in treating immunosuppressive disorders or proliferative diseases.

L'invention concerne des méthodes permettant de modifier l'activité du processus de signalisation de la PKA, ces méthodes consistant à modifier, de préférence par inhibition, l'étendue de la phosphorylation de substrats PKA ou de substrats kinase en aval, particulièrement grâce à l'utilisation de substrats modifiés, de séquences géniques codant pour ces substrats modifiés, de vecteurs et de cellules hôtes contenant ces séquences géniques, d'inhibiteurs de la phosphorylation de substrats et de l'utilisation desdites séquences géniques, et d'une protéine ou d'inhibiteurs destinés à modifier le processus de signalisation de la PKA, par exemple pour traiter les troubles immunosuppresseurs ou les maladies prolifératives.

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