C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/04 (2006.01) C12M 1/34 (2006.01) C12Q 1/00 (2006.01) G01N 15/10 (2006.01) G01N 33/483 (2006.01) G06T 5/40 (2006.01) G06T 7/60 (2006.01)
Patent
CA 2595118
A method for detecting malignancy-associated changes. A sample of cells is obtained and stained to identify the nuclear DNA material. The sample is imaged with a digital microscope. Objects of interest are identified in the sample of cells based on the intensity of the pixels that comprise the object versus the average intensity of all pixels in the slide image. An exact edge is located for each object and variations in the illumination intensity of the microscope are compensated for. A computer system calculates feature values for each object and, based on the value of the features, a determination is made whether the cell exhibits malignancy-associated changes or not.
Garner David Michael
Harrison S. Alan
Jaggi Bruno W.
Macaulay Calum Eric
Palcic Branko
Monogen Inc.
Smart & Biggar
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