Method and apparatus for capillary hydrodynamic fractionation

B - Operations – Transporting – 03 – B

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B03B 5/00 (2006.01) B01D 43/00 (2006.01) G01N 30/00 (2006.01) G01N 30/10 (2006.01) G01N 30/84 (2006.01) G01N 30/88 (2006.01)

Patent

CA 2049283

-18- Abstract This invention provides an apparatus and method for the complete fractionation of submicron particles according to size by capillary hydrodynamic fractionation. This objective is achieved by using small diameter capillaries; introducing a minor fraction of a liquid dispersion of particles to be separated into at least one capillary fraction; passing the minor fraction through the capillary; and, at the exit of the capillary, diluting the minor fraction with the same liquid as is carrying the fractionated sample. These modifications in the flow patterns are essential to the use of capillaries with diameters smaller than 60 microns. This invention is especially adapted for rapid analytical separation of not only rigid colloidal particles but also of soft latexes.

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