A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 25/01 (2006.01) A61B 18/24 (2006.01) A61L 31/16 (2006.01) A61M 31/00 (2006.01) A61B 17/00 (2006.01) A61B 17/22 (2006.01) A61B 18/22 (2006.01) A61F 2/00 (2006.01) A61F 2/06 (2006.01) A61M 1/36 (2006.01) A61M 25/00 (2006.01) A61M 25/06 (2006.01)
Patent
CA 2356717
A method and system for delivering a therapeutic agent directly to the heart employing minimally invasive techniques and concepts. In particular. the delivery of vascular endothelial growth factors (VEGF) is performed endovascularly or endoxopically to a region of a patient's heart treated with transmyocardial revascularization (TMR). A system is provided for inducing cardioplegic arrest. An aortic occlusion device has an inflatable balloon which occludes the ascending aorta when inflated. Cardioplegic fluid may be infused through a lumen of the aortic occlusion device to stop the heart while the patient's circulatory system is supported on cardiopulmonary bypass_ A side-firing fiberoptic laser is introduced through the aortic occlusion device in the endovascular technique to perform TMR. Subsequently, a therapeutic agent delivery catheter is directed into one of the coronary arteries to deliver and dissipate the VEGF into the surrounding vascular plexus to promote angiogenesis stimulation. Alternatively, a therapeutic agent delivery material saturated or coated with VEGF could be sutured to the epicardial surface of the heart, using thoracoxopic techniques. ~~~~~ ~~~~~ ~~~~~ ~~~~~ TMR treated site.
Brewer Richard
Gifford Hanson S.
Rosenman Daniel C.
Stevens John H.
Heartport Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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