Method and apparatus for destroying dividing cells

C - Chemistry – Metallurgy – 12 – N

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C12N 13/00 (2006.01) A61N 1/20 (2006.01) A61N 1/32 (2006.01)

Patent

CA 2400526

The present invention provides a method and apparatus for selectively destroying dividing cells in living tissue formed of dividing cells and non- dividing cells. The dividing cells contain polarizable intracellular members and during late anaphase or telophase, the dividing cells are connected to one another by a cleavage furrow. According to the present method the living tissue is subjected to electric field conditions sufficient to cause movement of the polarizable intracellular members toward the cleavage furrow in response to a non-homogenous electric field being induced in the dividing cells. The non-homogenous electric field produces an increased density electric field in the region of the cleavage furrow. The movement of the polarizable intracellular members towards the cleavage furrow causes the break down thereof which results in destruction of the dividing cells, while the non- dividing cells of the living tissue remain intact.

L'invention concerne un procédé et un dispositif permettant de détruire de manière sélective des cellules qui se divisent dans un tissu vivant comprenant des cellules qui se divisent et des cellules qui ne se divisent pas. Les cellules qui se divisent contiennent des éléments intracellulaires polarisables et à la fin de l'anaphase ou pendant la télophase les cellules en voie de division sont connectées l'une à l'autre par un sillon de clivage. Le présent procédé consiste à exposer le tissu vivant à un champ électrique suffisant pour provoquer un déplacement des éléments intracellulaires polarisables en direction du sillon de clivage en réponse à un champ électrique non homogène produit dans les cellules en voie de division. Ce champ électrique non homogène produit un champ électrique de densité accrue dans la région du sillon de clivage. Le déplacement des éléments intracellulaires polarisables en direction du sillon de clivage entraîne la rupture de ce dernier et provoque ainsi la destruction des cellules en voie de division tandis que les cellules ne se divisant pas, présentes dans le tissu vivant, restent intactes.

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