Method and apparatus for diagnosing pre-eclampsia

Details Method and apparatus for diagnosing pre-eclampsia Method and apparatus for diagnosing pre-eclampsia

A - Human Necessities

61

B

A61B 5/00 (2006.01) A61B 5/021 (2006.01) A61B 5/103 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2649562

A method is provided that allows a subject to be diagnosed as having one of a variety of hypertensive states, including pre-eclampsia, based on the measurement of a plurality of factors including the level of soluble fms-like tyrosine kinase 1 (sFlt-1), an obesity factor and optionally one or more additional factors, which may be physiological parameters or biomarkers. The method can be used to determine hypertensive states associated with pregnancy, or associated with anti-angiogenic drug therapy. The method is thus useful for diagnosing the hypertensive status of pregnant women, as well as patients undergoing anti-angiogenic treatment (e.g., chemotherapy).

L'invention concerne un procédé permettant le diagnostic d'un sujet souffrant d'une variété d'états hypertensifs, y compris la pré-éclampsie, ledit diagnostic étant fondé sur la mesure d'une pluralité de facteurs, y compris le niveau de tyrosine kinase 1 de type fms (sFlt-1) soluble, un facteur d'obésité et éventuellement un ou plusieurs facteurs supplémentaires, pouvant être des paramètres physiologiques ou des biomarqueurs. Le procédé peut être utilisé pour déterminer des états hypertensifs associés à la grossesse, ou associés à une thérapie médicamenteuse anti-angiogénique. Le procédé est donc utile pour diagnostiquer l'état hypertensif de femmes enceintes, ainsi que de patients subissant un traitement anti-angiogénique (p. ex. chimiothérapie).

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