Method and apparatus for direct in vivo gene transfer by...

Details Method and apparatus for direct in vivo gene transfer by... Method and apparatus for direct in vivo gene transfer by...

A - Human Necessities

61

M

A61M 35/00 (2006.01) C12N 15/87 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2347091

This invention is directed to a novel method for direct <i>in vivo</i> electrotransfection of a plurality of cells of a target tissue. In the method, the target is perfused with a transfection solution. An exterior electrode is positioned so as to surround at least a portion of the target tissue. One or more interior electrodes are placed within the target tissue. The perfusion and the application of the interior and exterior electrodes may be performed in any particular order. After the perfusion and the positioning of the electrodes, both interior and exterior, an electric waveform is applied through the exterior electrode and the interior electrode to transfect the cells in the target tissue.

L'invention concerne un nouveau procédé destiné à l'électrotransfection directe <i>in vivo</i> d'une pluralité de cellules d'un tissu cible. Selon ce procédé, le tissu cible est perfusé avec une solution de transfection. Au moins une partie du tissu cible est entourée d'une électrode externe. Une ou plusieurs électrodes internes sont placées à l'intérieur du tissu cible. La perfusion et la mise en place des électrodes internes et de l'électrode externe peuvent être réalisées dans n'importe quel ordre. Une fois la perfusion et la mise en place des électrodes internes et de l'électrode externe effectuées, on fait passer un signal électrique entre les électrodes internes et l'électrode externe afin de transfecter les cellules dans le tissu cible.

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