Method and apparatus for inactivation of biological...

A - Human Necessities – 61 – L

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A61L 2/08 (2006.01) A61L 2/00 (2006.01) A61L 2/10 (2006.01) A61M 1/36 (2006.01) A61M 1/02 (2006.01)

Patent

CA 2380832

Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to a fluid and exposing the fluid to photoradiation sufficient to activate the endogenous photosensitizer whereby microorganisms are inactivated. Other fluids, including juices, water and the like, may also be decontaminated by these methods as may surfaces of foods, animal carcasses, wounds, food preparation surfaces and bathing and washing vessel surfaces. Alloxazines and K- and L-vitamins are among the preferred photosensitizers. Systems and apparatuses for flow-through and batch processes are also provided for decontamination of such fluids using photosensitizers.

L'invention concerne des procédés et des appareils destinés à l'inactivation de micro-organismes présents dans des fluides ou sur des surfaces. De préférence, ces fluides contiennent du sang ou des produits sanguins et renferment des protéines bioactives. Selon les procédés préférés, on ajoute une dose efficace non toxique d'un photosensibilisant endogène à un fluide, puis on expose ce fluide à un photorayonnement suffisamment important pour activer le photosensibilisant endogène, lequel inactive alors les micro-organismes. Lesdits procédés permettent également de décontaminer d'autres fluides tels que des jus, de l'eau et analogues, ainsi que des surfaces d'aliments, de carcasses d'animaux et de blessures, des surfaces de préparation d'aliments et des surfaces de récipients de nettoyage et de cuves destinées au bain. Les alloxazines et les vitamines K et L figurent parmi les photosensibilisants préférés. L'invention concerne également des systèmes et des appareils de traitement continu et discontinu permettant la décontamination de ces fluides à l'aide des photosensibilisants précités.

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