Method and apparatus for measurement of blood substitutes

Details Method and apparatus for measurement of blood substitutes Method and apparatus for measurement of blood substitutes

G - Physics

01

N

G01N 21/25 (2006.01)

Patent

CA 2283154

A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method further takes the measured concentration of the blood substitute and uses it to correct for its effect, if any, on a measured analyte concentration, e.g., serum/plasma total protein. Further, the method allows for the determination of the concentration of true hemoglobin in the presence of blood substitutes. The method is carried out in respect of samples contained in a primary or secondary labelled tube, or a pipette tip used to dispense serum or plasma in a blood analyzer.

L'invention concerne une méthode qui permet d'identifier et de quantifier rapidement et précisément la concentration d'un succédané de sang, tel que l'hémoglobine réticulée, dans un échantillon de sérum ou de plasma. Selon la méthode, on mesure la concentration du succédané de sang et on utilise cette mesure pour corriger son effet, s'il existe, sur la concentration mesurée d'un analyte, tel que les protéines totales du sérum/plasma. La méthode permet de déterminer la concentration de l'hémoglobine vraie en présence des succédanés de sang. Elle est appliquée aux échantillons contenus dans un tube étiqueté primaire ou secondaire, ou à l'extrémité d'une pipette utilisée pour dispenser le sérum ou le plasma dans un analyseur.

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