Method and apparatus for measuring cancerous changes from...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01) A61B 5/1455 (2006.01) A61B 5/1459 (2006.01) G01N 21/47 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2595213

The present invention provides a new method and device for disease detection, more particularly cancer detection, from the analysis of diffuse reflectance spectra measured in vivo during endoscopic imaging. The measured diffuse reflectance spectra are analyzed using a specially developed light-transport model and numerical method to derive quantitative parameters related to tissue physiology and morphology. The method also corrects the effects of the specular reflection and the varying distance between endoscope tip and tissue surface on the clinical reflectance measurements. The model allows us to obtain the absorption coefficient (µa) and further to derive the tissue micro-vascular blood volume fraction and the tissue blood oxygen saturation parameters. It also allows us to obtain the scattering coefficients (µs and g) and further to derive the tissue micro-particles volume fraction and size distribution parameters.

L~invention concernée fournit un nouveau procédé et un nouvel appareil pour détecter une maladie, tout particulièrement le cancer, à partir de l~analyse de spectres de réflectance diffuse mesurés in vivo par imagerie endoscopique. Les spectres de réflectance diffuse mesurés sont analysés grâce à un modèle de transmission lumineuse spécialement conçu et un procédé numérique pour en extraire des paramètres quantitatifs sur la physiologie et la morphologie des tissus. Le procédé corrige également les effets de la réflexion spéculaire et les variations de distance entre l~extrémité de l~endoscope et la surface des tissus sur les mesures de réflectance clinique. Ce modèle permet d~obtenir un coefficient d~absorption (µa) et, par la suite, de calculer la fraction du volume de sang microvasculaire des tissus ainsi que leurs paramètres de saturation en oxygène sanguin. Il permet également d~obtenir les coefficients de dispersion (µs et g) et d~en déduire la fraction de volume des microparticules du tissu et les paramètres de répartition par taille.

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