Method and apparatus for objectively measuring pain, pain...

A - Human Necessities – 61 – B

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A61B 5/055 (2006.01) A61B 5/16 (2006.01)

Patent

CA 2403974

A method and apparatus for measuring indices of brain activity includes non- invasively obtaining signals of central nervous system (CNS) activity, localizing signals to specific anatomical and functional CNS regions, correlating the signals from pain and reward brain regions, and interpreting the correlation results. The results of interpreting the correlation results can be used for objectively measuring, in individual humans or animals, their responses to motivationally salient stimuli including but not limited to stimuli which are internal or external, conscious or non-conscious, pharmacological or non-pharmacological therapies, and diseased based processes. This method for measuring brain activity in reward/aversive central nervous system regions, can further be used to determine the efficacy of compounds.

Cette invention concerne une méthode et un dispositif permettant de mesurer des indices d'activité cérébrale. Cette méthode consiste à capter de manière non invasive des signaux produits par l'activité du système nerveux central (SNC), de localiser lesdits signaux dans certaines région anatomiques et fonctionnelles spécifiques du SNC, de mettre ces signaux en rapport avec des régions de la douleur et de la récompense et d'interpréter les résultats de la mise en corrélation. Les conclusions tirés de l'interprétation des résultats corrélés peut servir à mesure de manière objective, chez des humains et des animaux, les réponses à des stimuli saillants, notamment, mais pas exclusivement, des stimuli internes ou externes, conscients ou non conscients, des thérapies pharmacologiques ou non pharmacologiques et des processus pathologiques. Cette méthode de mesure de l'activité cérébrale dans les régions récompense/aversion du système nerveux central peut être étendue à la détermination de l'efficacité de composés.

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