A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
128/81.2
A61M 5/00 (2006.01) A61M 1/34 (2006.01)
Patent
CA 1163517
ABSTRACT OF THE INVENTION An on-line filtration system for the removal of macromolecules greater than 70,000 mol. wt. from a physio- logical solution, such as blood, in the therapeutic treat- ment of various disease states. For blood, the plasma (which contains the macromolecules) is separated continu- ously from the blood using a first membrane filter with a membrane porosity of nominally 0.2 to 1.0 micron. The separated plasma is then continuously filtered in a physi- ological temperature state or a cooled state through a second membrane filter with a membrane porosity of nomi- nally 0.01 to 0.2 micron, which retains the macromolecules. In the cooled state, separation of the macromolecules is effected more efficiently than could be done in the non- cooled state. The treated plasma (macromolecules removed) is then reunited with the blood flow coming from the first plasma filter and returned to the patient. The blood flow and filtration processes are generally continuous. Suit- able agent(s) may be added to the separated plasma to promote formation of macromolecules.
377362
Malchesky Paul S.
Nose Yukihiko
Japan Foundation For Artificial Organs
Macrae & Co.
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