Method and apparatus for producing a discrete particle

Details Method and apparatus for producing a discrete particle Method and apparatus for producing a discrete particle

H - Electricity

01

J

H01J 49/10 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) H01J 49/04 (2006.01) H01J 49/26 (2006.01)

Patent

CA 2324911

A method and apparatus for producing a discrete particle for subsequent analysis (such as mass spectrometry) or manipulation is disclosed. A discrete particle is generated by a particle generator. A net charge is induced onto the particle by an induction electrode. The particle is delivered to a levitation device where it is then electrodynamically levitated. If the particle is a droplet, desolvation will occur, leading to Coloumbic fissioning of the droplet into smaller droplets. The movement of the levitated droplet(s) can be manipulated by an electrode assembly. The droplet(s), and the charge thereon, can be delivered to a mass spectrometer in one aspect of the invention, providing an ion source for mass spectrometry without the detrimental space charge effects of electrospray ionization. techniques. In another aspect of the invention, the levitated particle(s) may be deposited onto a plate for subsequent analysis by matrix assisted laser desorption and ionization mass spectrometry.

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