Method and apparatus for reducing electroporation-mediated...

Details Method and apparatus for reducing electroporation-mediated... Method and apparatus for reducing electroporation-mediated...

A - Human Necessities

61

N

A61N 1/18 (2006.01) A61N 1/00 (2006.01) A61N 1/32 (2006.01)

Patent

CA 2368728

This invention is a method for delivery of an agent to a cell using electroporation (15) including positioning first, and second electrodes (16) such that an electrical signal passed therebetween passes through the cell. The method also includes passing an electrical signal of a frequency greater than about 10 kHz between the electrodes. In one embodiment the signal is a bipolar waveform. In another, the electrodes are positioned at a treatment site (30), e.g., a tumor (34), for in vivo delivery of an agent.

Un procédé permettant d'apporter à une cellule un agent par électroporation (15) consiste à positionner des première et deuxième électrodes (16) de sorte qu'un courant électrique traversant ces dernières pénètre dans la cellule. Ce procédé consiste également à faire passer un signal électrique d'une fréquence supérieure à environ 10 kHz entre lesdites électrodes. Dans une forme de réalisation, le signal est une onde bipolaire, et dans une autre forme de réalisation les électrodes sont positionnées au niveau d'un site de traitement (30), par exemple au niveau d'une tumeur (34) pour apporter un agent in vivo.

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