Method and apparatus for sample deposition

G - Physics – 01 – N

Patent

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Details

G01N 30/80 (2006.01) B01L 99/00 (2010.01) B01D 15/08 (2006.01) B01D 15/10 (2006.01) B01D 15/14 (2006.01)

Patent

CA 2592595

A method and apparatus is disclosed to prepare a sample or a plurality of samples for subsequent analysis. A single sample deposition apparatus, and a multiplexed sample deposition apparatus are shown. The apparatus allows for a system that can provide a high throughput deposition of samples to form chromatograms by discrete droplet deposition or as continuous traces. The system can achieve high resolution digitization by pulsing the fluid emanating from the chromatographs by applying a voltage to the target plate that operates at frequencies equal to or greater than about 10 Hz, and up to and including about 1 KHz. The system also allows for analogue recording (i.e., approaching infinite resolution) by nebulizing the fluid coming from multiple columns and simultaneously collecting it on a target plate as a continuous trace.

Cette invention concerne un procédé et un dispositif de préparation d'un ou de plusieurs échantillons pour analyse ultérieure. Sont décrits deux dispositifs de dépôt d'échantillons, l'un simple, l'autre multiplexé. Avec ces dispositifs, le système permet de déposer des échantillons à cadence élevée pour la formation de chromatogrammes par dépôt séparé de gouttelettes ou sous forme de traces continues. Ce système rend possible une numérisation à haute résolution par pulsation du fluide provenant des chromatographes, avec application à la plaque cible d'une tension sous des fréquences égales ou supérieures à 10 Hz environ, et jusqu'à environ 1 KHz. Le système autorise également un enregistrement analogue (c'est-à-dire proche d'une résolution infinie) par nébulisation du fluide provenant de colonnes multiples et collecte simultanée dudit fluide sur une plaque cible sous forme de trace continue.

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