Method and apparatus for synthesis of arrays of dna probes

Details Method and apparatus for synthesis of arrays of dna probes Method and apparatus for synthesis of arrays of dna probes

G - Physics

01

N

G01N 21/00 (2006.01) B01J 19/00 (2006.01) C07B 61/00 (2006.01) C07H 21/00 (2006.01) C08K 3/00 (2006.01) C12M 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 1/00 (2006.01) G01N 21/01 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G02B 26/08 (2006.01) G03F 7/20 (2006.01)

Patent

CA 2321070

The synthesis of arrays of DNA probe sequences, polypeptides and the like is carried out using a patterning process on an active surface of a substrate (12). An image is projected onto the active surface (15) utilizing an image former (11) that includes a light source that provides light to a micromirror device (35) comprising an array of electronically addressable micromirrors (36). The substrate (12) is activated in a defined pattern and bases are coupled at the activated sites, with further repeats until the elements of a two-dimensional array on the substrate have an appropriate base bound thereto. The micromirror array (35) can be controlled in conjunction with a DNA synthesizer to control the sequencing of images presented by the micromirror array (35) in coordination with the reagents provided to the substrate (12).

La présente invention concerne la synthèse de réseaux de séquences de sondes ADN, de polypeptides et analogues, que l'on effectue à l'aide d'un processus de formation de motif sur la surface active d'un substrat (12). On projette une image sur la surface active (15) à l'aide d'un dispositif de formation d'image (11) comprenant une source lumineuse qui fournit de la lumière à un dispositif de micromiroir (35) composé d'un champ de micromiroirs électroniquement adressables (36). Le substrat (12) est activé selon un motif défini et les bases sont couplées aux sites activés, ceci à plusieurs reprises jusqu'à ce qu'une base appropriée se soit fixée sur les éléments d'un tableau bidimensionnel formé sur le substrat. On peut commander le champ de micromiroirs (35) conjointement avec un synthétiseur d'ADN afin de régler le séquençage des images présentées par le champ de micromiroirs (35) en coordination avec les réactifs placés sur le substrat (12).

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