Method and apparatus for targeted drug delivery into a...

Details Method and apparatus for targeted drug delivery into a... Method and apparatus for targeted drug delivery into a...

G - Physics

01

R

G01R 33/28 (2006.01) A61M 31/00 (2006.01) A61M 25/00 (2006.01) G01R 33/563 (2006.01)

Patent

CA 2289837

The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at a target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.

Cette invention se rapporte à un appareil et à un procédé d'administration ciblée de médicament à un patient au moyen de l'imagerie par résonance magnétique (IRM). Cet appareil et ce procédé servent à l'administration de médicament à tous types de tissu vivant et font appel à l'imagerie par résonance magnétique pour suivre la trace du médicament administré et estimer la vitesse d'administration du médicament. Un dispositif d'administration de médicament par résonance magnétique visible, positionné au niveau d'un site cible (par exemple, en vue d'une administration intracrânienne) administre au tissu (par exemple, au tissu cérébral) une solution médicamenteuse diagnostique ou thérapeutique. La cinétique de distribution spatiale de l'agent médicamenteux injecté ou infusé fait l'objet d'une surveillance quantitative, non invasive, par IRM à diffusion directionnelle de protons dans l'eau permettant d'évaluer l'efficacité de l'administration du médicament au niveau de l'emplacement cible.

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