Method and apparatus for the delivery of polynucleotide...

Details Method and apparatus for the delivery of polynucleotide... Method and apparatus for the delivery of polynucleotide...

A - Human Necessities

61

N

A61N 1/30 (2006.01) A61K 39/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2684134

An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and reduce pain and discomfort due to long electric waveform application and due to musclc contractions. The method includes administering a polynuclcotidc vaccine into the skin at an administration site, (b ) applying a needle electmde to the skin in the vicinity to the administration site, and (c ) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the 15 polynucleotide vaccine into the skin cells by electroporation.

La présente invention a pour objet un procédé et un appareil pour la délivrance de vaccins polynucléotidiques dans des cellules cutanées de mammifères pour augmenter la réponse en lymphocytes T et réduire la douleur et l'inconfort dus à une application prolongée de sinusoïdes électriques et dus à des contractions musculaires. Le procédé comprend l'administration d'un vaccin polynucléotidique dans la peau à un site d'administration, (b) l'application d'une électrode aiguille sur la peau à proximité du site d'administration, et (c) l'application d'une séquence d'au moins trois sinusoïdes électriques simples à intervalles étroits, programmées indépendamment et contrôlées par l'opérateur, qui ont des intervalles de pulsion inférieurs à 100 millisecondes, pour délivrer le vaccin à 15 polynucléotides dans les cellules cutanées par électroporation.

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