Method and apparatus for the formation of particles

Details Method and apparatus for the formation of particles Method and apparatus for the formation of particles

B - Operations, Transporting

01

J

B01J 2/04 (2006.01) A61K 9/16 (2006.01) B05B 7/06 (2006.01) B05B 7/08 (2006.01)

Patent

CA 2278347

The invention provides a method and apparatus for forming particles of a substance, comprising (a) introducing into a particle formation chamber, the temperature and pressure in which are controlled, a first supercritical fluid (SCF) and a solution or suspension of the substance in a vehicle; (b) simultaneously introducing an impinging flow of a second supercritical fluid (SCF), at an angle to, and directed at, the direction of flow of the first supercritical fluid, so as to increase the amount of kinetic energy transferred to the solution or suspension; and (c) using either or both of the first and the second supercritical fluids to disperse the solution or suspension, and to extract the vehicle from it, substantially simultaneously and substantially immediately on introduction of the fluids into the particle chamber.

La présente invention concerne un procédé et un appareil destinés à la formation de particules d'une substance, consistant: a) à introduire à l'intérieur d'une chambre de formation de particules, où la température et la pression sont contrôlées, un premier fluide supercritique et une solution ou une suspension de la substance contenue dans un véhicule; b) à introduire en même temps un flux incident d'un second fluide supercritique allant dans le sens d'écoulement du premier fluide supercritique et formant un angle avec celui-ci, de manière à accroître la quantité d'énergie cinétique transmise à la solution ou à la suspension; et enfin, c) à utiliser l'un des premier ou second fluides supercritiques, ou les deux, pour disperser la solution ou la suspension, et à en extraire le véhicule pratiquement en même temps et immédiatement après introduction des fluides à l'intérieur de la chambre à particules.

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