Method and apparatus for the non-invasive measurement of...

A - Human Necessities – 61 – B

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A61B 6/00 (2006.01)

Patent

CA 2648931

A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.

L'invention concerne la mesure non invasive d'un tissu biologique révélant des informations concernant la fonction de ce tissu. De la lumière polarisée est dirigée sur le tissu, stimulant l'émission de fluorescence, en raison d'un ou plusieurs fluorophores endogènes dans le tissu. L'anisotropie de fluorescence est alors calculée. De telles mesures d'anisotropie de fluorescence sont alors utilisées pour évaluer l'état fonctionnel du tissu et pour identifier l'existence et la gravité des étapes de la maladie. Une telle évaluation peut être faite par comparaison d'un profil d'anisotropie de fluorescence avec un profil connu d'un témoin.

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