G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) G01N 33/86 (2006.01) C12M 3/00 (2006.01) G01N 21/05 (2006.01)
Patent
CA 2716269
Adhesion of platelets to blood vessel walls is the first step that promotes arrest of bleeding by interaction of the platelet receptors with various extracellular matrix proteins that become exposed on vascular injury. A flow chamber is provided for use in analyzing or studying platelet function, in whole blood, either as part of a batch process or in real time. In the flow chambers, an inert polydimethylsiloxane (PDMS) surface is plasma- activated and a homobifunctional cross-linker is used to immobilize platelet-binding proteins onto a chamber wall surface. Immobilized collagen and fibrinogen may thus be assayed by continuously monitoring the adhesion of ADP and Ca2+ activated platelets from a subject, such as a patient having normal or type 2 diabetes (T2D). The flow chamber provides a simplified and robust method for the construction flow chambers which enable the kinetic monitoring of platelet adhesion in whole blood.
Carriveau Edward C.j.
Kaur Harmanpreet
Mutus Bulent
Riches Mckenzie & Herbert Llp
University Of Windsor
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