A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 18/04 (2006.01) A61F 7/12 (2006.01) A61N 5/04 (2006.01)
Patent
CA 2476078
A method and apparatus (100) of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source (110) heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43 ~C for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source (110) activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy- emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.
L'invention concerne un procédé et un appareil de traitement thermothérapeutiques de tissus proches d'un conduit corporel qui permettent d'éviter l'obstruction de ce dernier par un oedème. Ce procédé consiste à injecter un médicament encapsulé dans un excipient thermosensible, tel qu'un liposome, dans la région du tissu à traiter. La chaleur produite par la source émettrice d'énergie porte une partie du tissu qui entoure le conduit corporel à une température avoisinant 43 ·C pendant un temps suffisamment long pour la détruire. Par ailleurs, la chaleur produite par la source émettrice d'énergie active l'excipient thermosensible pour favoriser la libération du médicament encapsulé lequel est ciblé vers le tissu à traiter. L'énergie focalisée de la source émettrice d'énergie, associée à la compression agissant sur la zone cible, permet d'administrer des médicaments à la zone cible et de donner au stent naturel une efficacité longue durée.
Fenn Alan J.
Mon John
Boston Scientific Corporation
Celsion Corporation
Sim & Mcburney
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