Method and assay system for neurotrophin activity

Details Method and assay system for neurotrophin activity Method and assay system for neurotrophin activity

C - Chemistry, Metallurgy

12

Q

C12Q 1/18 (2006.01) A61K 31/41 (2006.01) A61K 31/475 (2006.01) A61K 31/55 (2006.01) A61K 31/56 (2006.01) A61K 31/70 (2006.01) A61K 33/24 (2006.01) A61K 38/19 (2006.01) C07H 21/00 (2006.01) C07K 14/475 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2112799

2112799 9300909 PCTABS00019 The present invention describes a method of treating neurotrophin-expressing tumors comprising interrupting the autocrine survival loop by administering a pharmaceutically effective amount of a substance capable of interrupting the autocrine loop. As examples, antisense nucleic acids and K252a or its derivatives may be used in pharmaceutically acceptable compositions, to interrupt the autocrine loop of a tumor cell which depends on the neurotrophin it expresses for its survival. A model system for identifying other means of interrupting autocrines loop is also described.

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