Method and composition for ameliorating the adverse effects...

Details Method and composition for ameliorating the adverse effects... Method and composition for ameliorating the adverse effects...

A - Human Necessities

61

K

167/220, 167/310

A61K 31/52 (2006.01) A61K 7/48 (1995.01)

Patent

CA 1339503

6-(substituted amino)purine cytokinins, including kinetin, have been discovered to ameliorate the adverse effects of aging on mammalian cells, by slowing or reversing the morphological changes that normally accompany aging of such cells, without significantly increasing the growth rate or total proliferative capacity of such cells. Thus, methods are provided for countering the adverse effects of aging on cells in culture and in vivo which comprise administering to said cells an adverse-age-effect-ameliorative amount of kinetin or another 6-(substituted amino)purine cytokinin. Compositions for carrying out the methods are also provided. Among the preferred applications of the invention are the preservation of the health of mammalian cells in culture and, by application to human skin of kinetin-containing lotions, ointments or creams, the health and youthful appearance of the skin.

559960

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