A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/159, 167/237
A61K 9/06 (2006.01) A61K 31/165 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 45/06 (2006.01) A61K 47/22 (2006.01) A61N 1/30 (2006.01)
Patent
CA 2038097
Methods for enhancing the delivery of an active ingredient to the vasculature of an animal by iontophoresis have the steps of adding a vasoactivator to a formulation with an active ingredient, coiontophoresing the vasoactivator and the active ingredient into the skin of an animal and establishing a concentration of the vasoactivator in the skin near the upper capillary loops thereof so that the blood flow is changed therethrough. The vasoactivator effectively changes the blood flow in the upper capillary loops of the vasculature in the skin of an animal. If the vasoactivator is a vasodilator, the blood flow is increased and when the vasoactivator is a vasoconstrictor, the blood flow is decreased. The specification discloses iontophoretic delivery apparatus for use with a formulation for controlling iontophoretic transdermal administration of an active ingredient into the blood stream of the vasculature of an animal, and discloses methods and compositions for enhanced iontophoretic delivery of active agents. The compositions are pharmaceutically acceptable compositions for iontophoretic delivery comprising a delivery enhancing amount of a vasodilator or vasoconstrictor and active agent.
Riviere James E.
Sage Burton Henry Jr.
Gowling Lafleur Henderson Llp
University Of North Carolina
Vyteris Inc.
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