Method and composition for confirming the heat sterilization...

Details Method and composition for confirming the heat sterilization... Method and composition for confirming the heat sterilization...

G - Physics

01

N

150/1, 150/25

G01N 25/48 (2006.01) A61L 2/04 (2006.01) A61L 2/28 (2006.01) G01K 3/04 (2006.01) G01K 11/00 (2006.01)

Patent

CA 1043676

ABSTRACT OF THE DISCLOSURE The heat sterilization of parenteral solutions and the like can be confirmed by including with the parenteral solution, in a sterilizing temperature-time exposure, an isolated, aqueous solution of a polysaccharide which hydrolyzes to produce a monosaccharide, with the activation energy of hydrolysis being greater than 30 kilocalories per mole, and the frequency factor of such reaction being 1014 to 1022 min.-1; and thereafter analyzing the aqueous solution for effect of such exposure, to compare the effect with a predetermined standard effect which indicates exposure to a desired sterilizing temperature-time exposure.

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