Method and composition for determining the immunological...

Details Method and composition for determining the immunological... Method and composition for determining the immunological...

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 8/96 (2006.01) A61K 35/10 (2006.01)

Patent

CA 2122131

ABSTRACT OF THE DISCLOSURE The immunological activity of certain bioactive substances is determined by treating a human peripheral blood leukocyte (PBL) culture or a suspension of BALB/c mice resident peritoneal cells (RPC), with a solution of the substance to be tested in order to induce production of cytokines which then are determined according to standard identification methods; amplification of the results may be achieved by admixing - to the solution to be tested - a non- steroidal anti-inflammatory drug, preferably indomethacin. The method is also useful for determining the immunological response of a human individual to a therapy using a cytokine inducing substance.

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