A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 9/00 (2006.01) A61K 31/436 (2006.01) A61K 38/13 (2006.01) A61P 27/02 (2006.01)
Patent
CA 2464243
A method and composition for treating a dry eye condition by topically applying to the eye surfaces an emulsion forming a tear film that acts to lubricate the eye and to inhibit evaporation therefrom. The emulsion is constituted by water in which is dispersed a mixture that includes a phospholipid, a non-polar oil, a non-toxic emulsifying agent and a polar lipid that imparts a net positive charge to the film that is distributed throughout the film, causing the film to be electrostatically attracted to the anionic surface of the eye whereby the film adheres thereto and cannot be washed away. Includable in the mixture is a non-soluble therapeutic agent, such as cyclosporin which is effective against an eye disease and is delivered to the eye by the film.
L'invention concerne un procédé et une composition pour le traitement de l'oeil sec. Il s'agit d'administrer localement à la surface de l'oeil une émulsion formant un film lacrymal qui lubrifie l'oeil et qui inhibe l'évaporation depuis l'oeil. L'émulsion considérée est constituée d'eau renfermant une dispersion de mélange qui comprend un phospholipide, une huile non polaire, un émulsifiant non toxique et un lipide polaire conférant au film une charge positive nette répartie sur tout le film, et induisant une attraction électrostatique du film vis-à-vis de la surface anionique de l'oeil. En conséquence, le film adhère à la surface de l'oeil et ne peut pas être éliminé par rinçage. Le mélange décrit peut également renfermer un agent thérapeutique non soluble, du type cyclosporine, qui a une action préventive efficace contre une maladie des yeux et que le film lui-même fournit à l'oeil.
Benita Simon
Lambert Gregory
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Novagali Pharma Sa
Yissum Research Development Company Of The Hebrew University Of
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