A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/675 (2006.01) A61K 31/047 (2006.01) A61K 31/122 (2006.01) A61K 31/196 (2006.01) A61K 31/635 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2583315
The present invention relates to the surprising discovery that agents that increase intracellular accumulation of NADH + H+ enhance the anti-cancer effects of angiogenesis inhibitors. Furthermore, treatment of a mammal with a combination of at least one angiogenesis inhibitor and at least one agent that enhances intracellular accumulation of NADH + H+ allows for the enhanced treatment and/or prevention of ,angiogenic diseases and disorders.
L'invention concerne des agents qui augmentent l'accumulation intracellulaire de NADH+H+, renforcent les effets anticancéreux des inhibiteurs de l'angiogenèse. De plus, le traitement d'un mammifère au moyen d'une combinaison d'au moins un inhibiteur d'angiogenèse et d'au moins d'un agent renforçant l'accumulation intracellulaire de NADH+H+ assure le traitement et/ou la prévention renforcés de maladies et troubles angiogéniques.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Tiltan Pharma Ltd.
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