A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/00 (2006.01) A61K 31/395 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2624138
A method is described for increasing the engraftment efficiency of S/G2/M phase stem cells, which involves treating a recipient with the stromal cell- derived factor-1 (SDF-1) antagonist SDF-1G2 prior to delivery of the cells to said recipient. Further, a method of transplanting proliferating or S/G2/M phase stem cells is described, comprising the steps of: (a) obtaining stem cells; (b) inducing stem cells ex vivo to proliferate or enter S/G2/M phase; (c) treating the recipient with the SDF-1 antagonist SDF-1G2; and (d) providing the stem cells to the recipient.
L'invention concerne une méthode pour améliorer l'efficacité d'un greffage de cellules souches de phase S/G2/M. Cette méthode implique de traiter un receveur à l'aide d'un antagoniste de facteur 1 dérivé de cellules de stroma (SDF-1), avant d'injecter ces cellules au receveur. En outre, l'invention concerne une méthode de transplantation ou de prolifération de cellules souches de phase S/G2/M. Cette méthode comprend les étapes consistant à: (a) obtenir des cellules souches; (b) induire des cellules souches ex-vivo pour les faire proliférer ou pour les faire entrer en phase S/G2/M; (c) traiter le receveur à l'aide d'un antagoniste de SDF-1; et (d) fournir les cellules souches au receveur.
Borden Ladner Gervais Llp
British Columbia Cancer Agency Branch
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