Method and composition for inhibiting cellular irreversible...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/08 (2006.01) A01N 1/02 (2006.01) A23L 1/30 (2006.01) A61K 31/70 (2006.01) A61K 38/05 (2006.01) A61K 45/06 (2006.01) C07H 19/16 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2247461

Formulations of naturally occurring physiologically acceptable compounds and their derivatives are provided for treatment of cellular stress, particularly hypoxia. By administering the formulations, comprising for the most part purines, sugars, amino acids and physiologically acceptable derivatives thereof, by themselves or in combination with each other and with other compounds, particularly electron acceptor compounds, the time to irreversible cellular changes, particularly mortality, can be greatly extended.

L'invention concerne des formulations de composés naturels physiologiquement acceptables et leurs dérivés, permettant de traiter le stress cellulaire, et en particulier, l'hypoxémie. L'administration de ces formulations, comprenant essentiellement des purines, des sucres, des acides aminés et de leurs dérivés physiologiquement acceptables de ces derniers, seuls ou en association les uns avec les autres et avec d'autres composés, en particulier, des composés électroaccepteurs, permet de prolonger sensiblement la période jusqu'aux modifications cellulaires irréversibles, plus précisément, la mortalité.

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