Method and composition for pharmaceutical product

Details Method and composition for pharmaceutical product Method and composition for pharmaceutical product

A - Human Necessities

61

K

A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 31/513 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) A61P 31/18 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2611520

This invention is directed to a composition comprising dry granulated tenofovir DF and emtricitabine, and a inethod for making same. Dry granulation was unexpectedly found to be important in preparing a tenofovir DF containing composition suitable for inclusion in a combination dosage form containing emtricitabine, efavirenz and tenofovir DF.

L'invention concerne une composition comprenant des granulés de ténofovir DF et d'emtricitabine produits par voie sèche. Cette invention se rapporte en outre à un procédé de production de cette composition. Il a été découvert, de manière tout à fait inattendue, que le processus de granulation par voie sèche est important dans la préparation d'une composition contenant du ténofovir DF, qui est destinée à être incorporée dans une forme posologique combinée contenant de l'emtricitabine, de l'éfavirenz, et du ténofovir DF.

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