Method and composition for the regeneration of tissue with...

A - Human Necessities – 61 – K

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Details

A61K 35/14 (2006.01) A61K 35/16 (2006.01) A61K 35/28 (2006.01)

Patent

CA 2719437

The invention relates to a novel polymerizable composition, comprising substantially blood or blood plasma, and stem cells or cells of the bone marrow, and to a method for regenerating tissue with the aid of such compositions. Such mixtures can polymerize into viscous gels under the influence of endogenic or exogenic polymerization factors, such as thrombin, calcium ions or cell detritus, said gels being very advantageous for the development and differentiation of the stem or bone marrow cells into tissue-specific cells. Such polymers, comprising particularly also erythropoietin (EPO) or similarly acting growth factors, exhibit excellent properties in the use thereof for tissue regeneration or the regeneration of bone defects.

L'invention concerne une composition polymérisable d'un type nouveau, essentiellement constituée de sang ou de plasma sanguin, ainsi que de cellules souches ou de cellules de moelle osseuse. L'invention concerne également un procédé destiné à régénérer des tissus à l'aide de telles compositions. De tels mélanges peuvent, sous l'effet de facteurs de polymérisation endogènes ou exogènes, comme la trombine, des ions calcium ou des déchets cellulaires, se polymériser en gels visqueux qui sont très avantageux pour le développement et la différenciation de cellules souches ou de cellules de moelle osseuse en cellules spécifiques auxdits tissus. De tels polymérisats, qui contiennent en outre, notamment de l'érythropoïétine (EPO) ou des facteurs de croissance à action analogue, présentent d'excellentes propriétés losqu'ils sont utilisés pour régénérer des tissus ou des os présentant des défauts.

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