Method and composition for the treatment of angiogenesis

Details Method and composition for the treatment of angiogenesis Method and composition for the treatment of angiogenesis

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 31/592 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2409759

We have now discovered that partially deglycosylated vitamin D binding protein (DBP-maf) is anti-tumorigenic not wholly via an immune mechanism but in part via an antiangiogenic mechanism. Accordingly, the present invention relates to use of DBP-maf in the treatment of diseases associated with increased or abnormal angiogenesis and/or endothelial cell differentiation. Preferably, the DBP-maf is administered to the patient by sustained release or in pulses. Pulse therapy is not a form of discontinuous administration of the same account of a composition over time, but comprises administration of the same dose of the composition at a reduced frequency or administration of reduced doses.

Nous avons découvert que la protéine de fixation de la vitamine D partiellement déglycosylée (DBP-maf) n'est pas entièrement antitumorigène via un mécanisme immunitaire, mais en partie via un mécanisme antiangiogénique. Par conséquent, la présente invention concerne l'utilisation de la protéine DBP-maf dans le traitement de maladies associées à une angiogenèse importante ou anormale et/ou à une différentiation des cellules endothéliales. De préférence, la protéine DBP-maf est administrée à un patient de façon continue ou périodique. L'administration périodique n'est pas une administration discontinue d'une même dose d'une composition sur un laps de temps donné, mais comprend l'administration de la même dose de cette composition à une fréquence inférieure ou l'administration de doses réduites.

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