Method and composition for the treatment of cancer

Details Method and composition for the treatment of cancer Method and composition for the treatment of cancer

A - Human Necessities

61

K

A61K 31/352 (2006.01) A61K 31/122 (2006.01) A61K 31/337 (2006.01) A61K 31/35 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2369303

We have surprisingly discovered that the administration of a G1 and/or S phase drug such as .beta.-lapachone in combination with a G2/M drug such as a taxame derivative such as paclitaxel resulted in an unexpected greater than additive (i.e., synergistic) reduction in the number of tumors (and tumor volume) as compared with the administration of these agents alone. In addition, no signs of toxicity or weight loss were observed. The present invention relates to a method for treating a mammalian tumor using combinations such as a taxane derivative, preferably paclitaxel, and a .beta.-lapachone, or a derivative or analog thereof.

On a découvert avec surprise que l'administration d'un médicament visant les cellules en phase G1 et/ou S tel que la .beta.-lapachone en combinaison avec un médicament visant les cellules en phase G2/M tel qu'un dérivé de taxane comme le paclitaxel a provoqué une réduction imprévisiblement supérieure que celle produite par un effet additif (par exemple synergique), du nombre des tumeurs (volume des tumeurs) comparativement à l'administration de ces seuls agents. En outre, aucun signe de toxicité ni de perte de poids n'a été observé. La présente invention concerne un procédé de traitement d'une tumeur de mammifère à l'aide de combinaisons telles que celles formées d'un dérivé de taxane, de préférence du paclitaxel et d'une .beta.-lapachone, ou d'un dérivé ou d'un analogue de cette dernière.

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