Method and composition for the treatment of lipid and...

A - Human Necessities – 61 – K

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Details

A61K 31/55 (2006.01) A61K 31/48 (2006.01) A61K 31/4985 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2254116

This invention is directed to modifying or regulating in a subject of at least one of lipid and glucose metabolism by administering to a subject in need of such treatment a dopamine D1 agonist in conjunction with one agent or agent combination selected from i) a dopamine D2 agonist, ii) at least one of an adrenergic alphal antagonist, an adrenergic alpha2 agonist and a serotonergic inhibitor, or iii) a dopamine D2 agonist further conjoined with at least one of an adrenergic alphal antagonist, an adrenergic alpha2 agonist and a serotonergic inhibitor.

Cette invention a trait à la modification ou à la régulation, chez un sujet, soit du métabolisme des lipides, soit de celui du glucose, par l'administration au sujet exigeant un tel traitement, d'un agoniste de la dopamine D1 et ce, concurremment à un agent ou à une combinaison d'agents choisis dans le groupe constitué des substances suivantes: (i), un agoniste de la dopamine D2, (ii), un antagoniste alpha-1 adrénergique, un agoniste alpha-2 adrénergique ou un inhibiteur sérotoninergique ou bien (iii), un agoniste de la dopamine D2 associé, par ailleurs, à un antagoniste alpha-1 adrénergique ou à un agoniste alpha-2 adrénergique ou à un inhibiteur sérotoninergique.

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