Method and composition for treating and preventing tuberculosis

Details Method and composition for treating and preventing tuberculosis Method and composition for treating and preventing tuberculosis

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/366 (2006.01) A61K 31/37 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2346813

Calanolides and analogues thereof that demonstrate potent mycobacterium activity are provided. Also provided is a method of using calanolides and analogues thereof for treating or preventing mycobacterium infections. The calanolides and analogues thereof provided are obtained via syntheses employing chromene 4 and chromanone 7 as key intermediates.

La présente invention concerne des calanolides et des analogues associés qui démontrent une activité anti-mycobactérie puissante. L'invention concerne aussi une méthode d'utilisation des calanolides et de leurs analogues destinés à traiter ou à prévenir de infections de mycobactérie. Les calanolides et leurs analogues concernés sont obtenus via des synthèses utilisant le chromène 4 et la chromanone 7 en tant qu'intermédiaires clés.

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