A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/275 (2006.01) A61K 31/713 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/26 (2006.01) G01N 33/573 (2006.01) C07K 16/40 (2006.01) C12N 9/06 (2006.01)
Patent
CA 2650597
Methods, compositions and kits are provided for effectively treating and preventing cancer metastasis in vivo and for increasing survival of subjects burdened with metastatic tumors by targeting a lysyl oxidase or its modulator, especially human lysyl oxidase. Also provided are methods for identifying lysyl oxidase inhibitors and the use of such inhibitors to prevent and treat tumors, particularly metastatic tumors, alone and in combination with chemotherapeutic agents. Further disclosed is the use of lysyl oxidase levels for measuring metastatic potential and survival.
L'invention concerne des procédés, des compositions et des kits destinés à traiter et à prévenir efficacement des métastases cancéreuses in vivo et à augmenter la survie de sujets atteints de tumeurs métastatiques en ciblant une lysyle oxydase ou son modulateur, notamment la lysyle oxydase humaine. L'invention concerne également des procédés d'identification d'inhibiteurs de la lysyle oxydase et l'utilisation de ces inhibiteurs pour la prévention et le traitement de tumeurs, en particulier de tumeurs métastatiques, seuls et en combinaison avec des agents chimiothérapeutiques. L'invention concerne en outre l'utilisation des taux de lysyle oxydase pour mesurer le potentiel métastatique et la survie.
Erler Janine
Giaccia Amato
Gowling Lafleur Henderson Llp
The Board Of Trustees Of Leland Standford Junior University
LandOfFree
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