A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5575 (2006.01) A61P 35/00 (2006.01) C07C 405/00 (2006.01)
Patent
CA 2601158
Provided is a method and composition for treating mucosal disorders using a specific prostaglandin compound. The prostaglandin compound induces a conformational change in the tight junction that results in recovery of mucosal barrier function. Accordingly, the prostaglandin compound used herein is useful for the treatment of mucosal disorders.
La présente invention a trait à un procédé et une composition pour le traitement de troubles de la muqueuse mettant en oeuvre un composé à base de prostaglandine. Le composé à base de prostaglandine induit une modification conformationnelle dans la jonction serrée qui entraîne la récupération de la fonction barrière mucosale. Par conséquent, le composé à base de prostaglandine utilisé dans le procédé de l'invention est utile pour le traitement de troubles de la muqueuse.
Blikslager Anthony T.
Kuno Sachiko
Moeser Adam J.
Ueno Ryuji
Kirby Eades Gale Baker
North Carolina State University
Sucampo Ag
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