Method and composition for treating thrombosis

Details Method and composition for treating thrombosis Method and composition for treating thrombosis

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) A61K 38/12 (2006.01) C07K 7/54 (2006.01) C07K 14/705 (2006.01) C07K 14/745 (2006.01) C07K 14/75 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2079606

2079606 9115515 PCTABS00007 The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and contain hydrophobic moieties adjacent to the carboxy terminus of the RGD sequence. Peptides of this nature are also provided which contain in addition to the hydrophobic moiety an adjacent positively charged moiety. Such peptides have a high affinity for the receptor IIb/IIIa and a low affinity for the fibronectin and vitronectin receptors. Such peptides can be administered in a suitable physiologically acceptable carrier to therapeutically treat thrombosis.

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