Method and composition having enhanced alpha-hydroxy skin...

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A61K 8/64 (2006.01) A61K 31/195 (2006.01) A61K 45/06 (2006.01) A61K 47/12 (2006.01) A61K 7/48 (1995.01)

Patent

CA 2142940

Methods of enhancing skin permeation and skin retention of ?-hydroxy acids for the treatment of dermatological disorders by applying a composition containing an amphoteric salt of an ?- hydroxy acid, such as lactic, glycolic, citric, tartaric or malic acid and an amino acid, dipepdide, polypeptide or proteins, in a dermatologically acceptable carrier which contains 0.5 to 8% glycerol monocaprylate, 0 to 80% petrolatum and 0 to 30% isopropyl myristrate, the pH of the composition being from 3 to 9, and compositions for practicing such methods.

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