A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/495 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/496 (2006.01)
Patent
CA 2317106
The present invention relates to a method and composition of an oral preparation of itraconazole, an excellent azole antifungal drug. More particularly, it relates to an oral preparation of itraconazole having improved bioavailability, which is prepared by following steps of: i) dissolving itraconazole and hydrophilic polymer with solvent, ii) spray- drying said mixture, and iii) preparing the solid dispersions for oral preparation. The solid dispersions prepared in this invention may be useful in preparing tablets, granules and other oral dosage forms.
L'invention concerne un procédé et une composition comprenant une préparation d'itraconazole, excellent médicament antifongique à l'azole. Plus précisément, l'invention porte sur une préparation orale d'itraconazole ayant une biodisponibilité accrue, que l'on prépare de la manière suivante: i) dissoudre de l'itraconazole et un polymère hydrophile avec du solvant, ii) sécher ledit mélange par atomisation, et iii) préparer les dispersions solides pour la préparation orale. Les dispersions solides préparées selon l'invention peuvent être utiles dans la préparation de comprimés, de granulés et d'autres formes posologiques orales.
Hong Ji Woong
Jung Jae Young
Kim Kye Hyun
Lee Kyu Hyun
Lee Sang Heon
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Choongwae Pharma Corporation
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