Method and composition to reduce myocardial reperfusion injury

Details Method and composition to reduce myocardial reperfusion injury Method and composition to reduce myocardial reperfusion injury

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/165 (2006.01) C07H 19/067 (2006.01)

Patent

CA 2103458

This invention relates to a method to treat a heart attack victim to reduce heart muscle damage. In particular, the invention relates to a method to reduce myocardial reperfusion injury by selectively administering a nonhypotensive amount of a compound that selectively activates adenosine-1 receptor, a compound that selectively activates adenosine-2 receptor, or an adenosine, all in the presence of an effective amount of lidocaine.

Méthode de traitement des attaques cardiaques permettant de réduire les dommages causés aux muscles cardiaques. L'invention concerne en particulier une méthode permettant de réduire la blessure du myocarde due au rétablissement de la circulation en administrant une quantité n'ayant pas pour effet de faire baisser la tension d'un composé qui active sélectivement le récepteur de l'adénosine-1, un composé qui active sélectivement le récepteur de l'adénosine-2, ou une adénosine, le tout en présence d'une quantité efficace de lidocaïne.

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