C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 47/48 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) C07K 16/08 (2006.01) C07K 16/12 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2520389
The present invention provide a bispecific molecule comprising an antibody that binds a C3b-like receptor linked to one or more non-neutralizing antigenbinding antibodies or fragments thereof. The present invention also provides methods to identify non-neutralizing antibodies, and particularly, to identify enhancing antibodies. Methods of producing such bispecific molecules and their therapeutic and/or prophylactic uses are also provided by the present invention
L'invention concerne une molécule bispécifique comprenant un anticorps reliant un récepteur de type C3b relié à un ou à plusieurs anticorps se liant à un antigène non neutralisant ou à des fragments de celui-ci. L'invention concerne également des méthodes permettant d'identifier des anticorps non neutralisants, et en particulier, d'identifier des anticorps d'amélioration. L'invention concerne des méthodes de production de telles molécules bispécifiques et leurs utilisations thérapeutiques et/ou prophylactiques.
Casey Leslie S.
Mohamed Nehal
Spitalny George L.
Elusys Therapeutics Inc.
Gowling Lafleur Henderson Llp
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